Interplay of brain structure and function in neonatal congenital heart disease
نویسندگان
چکیده
OBJECTIVE To evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate with neuronal network dysfunction measured by analysis of EEG connectivity. METHODS We studied a prospective cohort of 20 neonates with CHD who underwent continuous EEG monitoring before surgery to assess functional brain maturation and network connectivity, structural magnetic resonance imaging (MRI) to determine the presence of brain injury and structural brain development, and diffusion tensor MRI to assess brain microstructural development. RESULTS Neonates with MRI brain injury and delayed structural and microstructural brain development demonstrated significantly stronger high-frequency (beta and gamma frequency band) connectivity. Furthermore, neonates with delayed microstructural brain development demonstrated significantly weaker low-frequency (delta, theta, alpha frequency band) connectivity. Neonates with brain injury also displayed delayed functional maturation of EEG background activity, characterized by greater background discontinuity. INTERPRETATION These data provide new evidence that early structural and microstructural developmental brain abnormalities can have immediate functional consequences that manifest as characteristic alterations of neuronal network connectivity. Such early perturbations of developing neuronal networks, if sustained, may be responsible for the persistent neurocognitive impairment prevalent in adolescent survivors of CHD. These foundational insights into the complex interplay between evolving brain structure and function may have relevance for a wide spectrum of neurological disorders manifesting early developmental brain injury.
منابع مشابه
گزارش یک مورد سندرم لوپوس نوزادی
Neonatal lupus syndrome is a rare disease. The manifestations of this disease in neonatal period include congenital heart block, cutaneous leasions, liver disease, thrombocytopenia, Neutropenia, pulmonary and nurologic derangements. Most of the clinical manifestations ofter disappear spontaneously. Although congenital heart block is usually permanent, and often require pacemakers. Congenital he...
متن کاملEvaluation of Brain Natriuretic Peptide, Tumor Necrosis Factor and Interleukin-6 Plasma Levels in Infants and Children with Congenital Heart Disease
Background Congenital heart disease (CHD) is the most common cause of major congenital birth defect. The aim of this study was to investigate the association of CHD with serum levels of Tumor necrosis factor-α (TNFα), Interleukin 6 (IL-6), and B-type Natriuretic Peptide (BNP) in infant and children. Materials and Methods The present study was conducted in Heshmat heart hospital and 17 Shahrivar...
متن کاملAssessment of the frequency and causes of heart consulting in patients admitted to the neonatal intensive care unit
Background: Congenital heart diseases are the second group of congenital anomalies in infants. These disorders are a major cause of death in the first year of a child's life. Early detection helps to treat these diseases better. In this study cardiology consultations of hospitalized infants in the neonatal intensive care unit were evaluated. Methods: In this cross-sectional study, two hundred ...
متن کاملComplete Congenital Heart Block in a Neonatal Lupus Erythematosus Associated with Pulmonary Involvement without Pacemaker Implantation: A Case Report
Background: Neonatal lupus erythematosus is an uncommon disease. Congenital complete heart block (CCHB) usually happens in neonates with maternal systemic lupus erythematosus. The most prevalent presentation of CCHBis bradycardiathatcanbediagnosed through an electrocardiogram. Case report: Here in, we present the case of a full-term male neonate with gestational age of 37 weeks and birth weigh...
متن کاملFrequency of Congenital Heart Disease in Neonates with Extra Cardiac Anomalies
Background Diagnosis of congenital heart disease (CHD) in neonates with extra cardiac anomalies is effective in their clinical management and surgical outcomes. This study aimed to investigate the frequency of CHD in neonates with extra cardiac anomalies admitted to a neonatal intensive care unit (NICU). Material...
متن کامل